Effect of Short- and Long-Term Stress on Plasma Calcium and Calcitonin in the Rat

S. Morimoto; A. Fausto; S. J. Birge; L. V. Avioli

doi:10.1055/s-2007-1012447

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1986; 18(12): 818-820
DOI: 10.1055/s-2007-1012447

ORIGINALS

Basic
© Georg Thieme Verlag, Stuttgart · New York

Effect of Short- and Long-Term Stress on Plasma Calcium and Calcitonin in the Rat

S. Morimoto, A. Fausto, S. J. Birge, L. V. Avioli

Department of Bone and Mineral Metabolism, The Jewish Hospital of St. Louis and Washington University School of Medicine, Saint Louis, Missouri, U.S.A.

Abstract

PDF Download

Summary

Although hypocalcemia has been observed during stress, the cause(s) is still unknown. The effect of short- and long-term restraint stress on calcitonin (CT) secretion and on plasma calcium (Ca), inorganic phosphate (P), total protein (TP), and corticosterone (CORT) were investigated in the male and female Sprague-Dawley rat. The rats were restrained in the supine position for two hours/day for either one day (STS) or for 14 days (LTS), and compared to normal controls (CON). Plasma Ca levels in both STS and LTS rats were significantly lower and mean plasma CORT levels in female stressed rats were significantly higher than those in sex-matched CON rats. However, mean basal levels of plasma CT did not differ among these three groups for either sex. Similarly, mean increment of plasma CT after Ca infusion (Ca 10 mg/100 g, i.v.) did not differ between STS or LTS rats and CON rats. These data reveal no causal relationship between CT and the hypocalcemia during either short- or long-term stressful stimuli.

Key-Words

Stress - Hypocalcemia - Calcitonin

PDF (290 kb)